Test for sex-linked lethals in irradiated mice
نویسندگان
چکیده
منابع مشابه
Spontaneous Mutation Rates for Sex-Linked Lethals in the Two Sexes of DROSOPHILA MELANOGASTER.
HE spontaneous mutation rates for autosomal lethals (both second and third chromosomes) in both male and female Drosophila melanogaster were reported in an earlier study (WALLACE 1968). Nearly 12.000 gametes obtained from lethal-free individuals were tested; the proportion of lethal-bearing ones was approximately 0.006 for either autosome and for either sex. The finding that the mutation rates ...
متن کاملChemically Induced Somatic and Gonadal Mosaicism in Drosophila. I. Sex-Linked Lethals.
HE sex-linked lethal test provides an objective, quantitative approach to Tmutagenesis in Drosophila. For radiation mutagenesis the analysis is usually limited to a single generation, the F, progeny of irradiated PI males or females. This procedure was established by MULLER (1928), who demonstrated that the bulk of induced mutations were present in these F, cultures. The sampling of single fema...
متن کاملMicronucleus test in mice fed on an irradiated diet.
A mutagenicity study was carried out in mice fed on a gamma-irradiated diet. As an indicator of mutagenic activity, we observed an incidence of micronuclei in erythrocytes. The average body weight of the mice fed on the diet irradiated to dose range of 400-1,000 kGy decreased, and the mice fed on the 800-1,000 kGy-irradiated diet died during the period from 8 to 14 days after the start of feedi...
متن کاملChemical induction of dominant lethals in female mice.
N female mammals, reduction in the number of live embryos following preI fertilization treatment with chemical mutagens could be due to genetic damage or to the interference by the agent with normal oogenesis, ovulation, fertilization, or maternal physiology. Such factors, which make dominant-lethal induction studies in adult female mammals difficult, have been dealt with in detail (RUSSELL 196...
متن کاملStudies on the Sex - Specific Lethals of Drosophila Melanogaster
Mutants at three male-specific lethal loci of Drosophila melanogaster (mle, m ~ l 2 ~ ' and mle(31132) were examined by gynandromorph analysis. In all cases only a very few gynandromorphs with small X/O patches appeared. Most of these small X/O patches were in the abdomen, and the structures in these X / O regions were reduced in size. These results indicate that the primary effects of these mu...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1962
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672300003281